ea0025p192 | Endocrine tumours and neoplasia | SFEBES2011
Kandasamy Narayanan
, Nik-Zainal Serena
, Annamalai Anand Kumar
, Walker Lisa
, Happerfield Lisa C
, Arends Mark J
, Patterson Joan
, Gurnell Mark
We report the first case of familial adrenocortical carcinoma (ACC) in association with hereditary non-polyposis colorectal cancer (HNPCC) in a family with a MSH2 germline mutation.HNPCC, an autosomal dominant disorder caused by mutations in one of the DNA mismatch repair (MMR) genes, is the commonest cause of hereditary colon carcinoma, and is associated with an increased risk of certain non-colonic cancers (e.g. endometrial, ovarian, urin...